Gene structure

What do we need to not be irritable, restless and discontented? Valium is not the right treatment for alcoholism or drug addiction. In the 70s, we gave everybody Valium. They quit drinking and got addicted to the Valium. Then they went back to the drinking until they were addicted to both Valium and drinking. Alcohol and Valium work together in the GABA-anergic system. Alcohol is water soluble, so it will go anywhere, but it's main impact is in the GABA system. So the brain has its own internal regulatory mechanism for pain, pleasure and reward.

Second messengers

 

 

 

 

Here you see the dopamine coming through the synaptic cleft and going into the receptor sites and that gets real complicated. These are the second messengers. That's the first messenger but run it down into the nucleus itself. This over here is called the express gene - the gene that determines everything.

Mice are alcohol avoidant, unless you breed a special strain. Today, neuroscientists can put a gene on a virus and run it into a mouse's brain, knock off a gene, insert another and build an alcoholic mouse. Then they can reverse the process. They can determine the whole genome of that mouse. We know this could be done on humans too, but no one has volunteered for it, as about 25% of the mice die. One day, a child born with a genome that indicates high risk for alcoholism and drug addiction, will be able to have their gene structure changed. This is truly Frankensteinian research which makes cloning look easy.

So the disease risk is genetic. You can't make an alcoholic - they are born. Some people who get addicted to drugs don't have this disease, I can promise you that. I don't know whether that’s the case for sexual compulsivity and I'm not sure anybody else does either. (Whether someone has the disease or whether they are just acting out, we'll treat them all the same way). But we are looking at the major gene structure for answers to compulsivity disorders too.

 

 

 

 

 

 

 

 

Mice are alcohol avoidant, unless you breed a special strain. Today, neuro-scientists can put a gene on a virus and run it into a mouse's brain, knock off a gene, insert another and build an alcoholic mouse. Then they can reverse the process. They can determine the whole genome of that mouse. We know this could be done on humans too, but no one has volunteered for it, as about 25% of the mice die. One day, a child born with a genome that indicates high risk for alcoholism and drug addiction, will be able to have their gene structure changed. This is truly Frankensteinian research which makes cloning look easy.

So the disease risk is genetic. You can't make an alcoholic - they are born. Some people who get addicted to drugs don't have this disease, I can promise you that. I don't know whether that’s the case for sexual compulsivity and I'm not sure anybody else does either. (Whether someone has the disease or whether they are just acting out, we'll treat them all the same way). But we are looking at the major gene structure for answers to compulsivity disorders too.